Cell atlas - AGFG1 - The Human Protein Atlas

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AGFG1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	AGFG1
Gene description	ArfGAP with FG repeats 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA008741
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008741	A-431	Vesicles
	HPA008741	U-2 OS	Vesicles
	HPA008741	U-251 MG	Vesicles

GENE INFORMATION
Gene name	AGFG1 (HGNC Symbol)
Synonyms	HRB, RAB, RIP
Description	ArfGAP with FG repeats 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Chromosome	2
Cytoband	q36.3
Chromosome location (bp)	227472152 - 227561214
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173744 (version 83.38)
Entrez gene	3267
UniProt	P52594 (UniProt - Evidence at protein level)
neXtProt	NX_P52594
Antibodypedia	AGFG1 antibodies

PROTEIN BROWSER

AGFG1-001	AGFG1-002	AGFG1-003	AGFG1-004	AGFG1-005	AGFG1-006	AGFG1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGFG1-001 ENSP00000312059 ENST00000310078	P52594 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005643 [nuclear pore] GO:0006406 [mRNA export from nucleus] GO:0007275 [multicellular organismal development] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	562 aa 58.3 kDa	No	0
AGFG1-002 ENSP00000362775 ENST00000373671	P52594 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005643 [nuclear pore] GO:0006406 [mRNA export from nucleus] GO:0007275 [multicellular organismal development] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	522 aa 54.2 kDa	No	0
AGFG1-003 ENSP00000387282 ENST00000409979	P52594 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001675 [acrosome assembly] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005643 [nuclear pore] GO:0006406 [mRNA export from nucleus] GO:0007275 [multicellular organismal development] GO:0007289 [spermatid nucleus differentiation] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0045109 [intermediate filament organization] GO:0046872 [metal ion binding] Show all	584 aa 60.8 kDa	No	0
AGFG1-004 ENSP00000387154 ENST00000409315	B8ZZY2 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	541 aa 56.4 kDa	No	0
AGFG1-005 ENSP00000387218 ENST00000409171	P52594 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005643 [nuclear pore] GO:0006406 [mRNA export from nucleus] GO:0007275 [multicellular organismal development] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	560 aa 58.1 kDa	No	0
AGFG1-006 ENSP00000405429 ENST00000456594	C9J2I0 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043231 [intracellular membrane-bounded organelle] Show all	238 aa 25.5 kDa	No	0
AGFG1-008 ENSP00000396469 ENST00000458212	H7C0S7 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 13.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.