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AGFG1

GENERAL INFORMATION

Gene name

 AGFG1

Gene description

 ArfGAP with FG repeats 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression with variable levels in most tissue types, including placenta testis and bone marrow.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA008741
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), ovarian cancer (unfavourable), lung cancer (unfavourable), renal cancer (unfavourable), cervical cancer (unfavourable) and glioma (favourable).
Liver cancer p<0.001
Ovarian cancer p<0.001
Lung cancer p<0.001
Renal cancer p<0.001
Cervical cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008741

GENE INFORMATION

Gene name

 AGFG1 (HGNC Symbol)

Synonyms

 HRB, RAB, RIP

Description

 ArfGAP with FG repeats 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 2

Cytoband

 q36.3

Chromosome location (bp)

 227472152 - 227561214

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173744 (version 83.38)

Entrez gene

 3267

UniProt

 P52594 (UniProt - Evidence at protein level)

neXtProt

 NX_P52594

Antibodypedia

 AGFG1 antibodies

PROTEIN BROWSER
AGFG1-001
AGFG1-002
AGFG1-003
AGFG1-004
AGFG1-005
AGFG1-006
AGFG1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGFG1-001
ENSP00000312059
ENST00000310078
P52594 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0006406 [mRNA export from nucleus]
GO:0007275 [multicellular organismal development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
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 562 aa
58.3 kDa 		No 0
AGFG1-002
ENSP00000362775
ENST00000373671
P52594 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0006406 [mRNA export from nucleus]
GO:0007275 [multicellular organismal development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
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 522 aa
54.2 kDa 		No 0
AGFG1-003
ENSP00000387282
ENST00000409979
P52594 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001675 [acrosome assembly]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0006406 [mRNA export from nucleus]
GO:0007275 [multicellular organismal development]
GO:0007289 [spermatid nucleus differentiation]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0045109 [intermediate filament organization]
GO:0046872 [metal ion binding]
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 584 aa
60.8 kDa 		No 0
AGFG1-004
ENSP00000387154
ENST00000409315
B8ZZY2 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 541 aa
56.4 kDa 		No 0
AGFG1-005
ENSP00000387218
ENST00000409171
P52594 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0006406 [mRNA export from nucleus]
GO:0007275 [multicellular organismal development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 560 aa
58.1 kDa 		No 0
AGFG1-006
ENSP00000405429
ENST00000456594
C9J2I0 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0043231 [intracellular membrane-bounded organelle]
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 238 aa
25.5 kDa 		No 0
AGFG1-008
ENSP00000396469
ENST00000458212
H7C0S7 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 132 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.