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Several hepatocellular carcinomas, urothelial cancers and melanomas along with a few gliomas and colorectal cancers displayed weak to moderate cytoplasmic and/or nuclear positivity. Cases of lung adenocarcinomas showed moderate to strong staining. Remaining cancers were negative.
Most cancers showed weak to moderate cytoplasmic immunoreactivity. Carcinoids, liver, prostate and skin cancers along with most lymphomas, testicular and lung cancers were negative.
Several carcinoids, lymphomas, melanomas, thyroid, urothelial and breast cancers along with few colorectal, stomach and skin cancers displayed moderate nuclear staining with occasional cytoplasmic positivity. Other cancer tissues were generally weakly stained or negative.
GENE INFORMATION
Gene name
STAT5B
Synonyms
Description
Signal transducer and activator of transcription 5B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
P51692 [Direct mapping] Signal transducer and activator of transcription 5B
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Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000255 [allantoin metabolic process] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001553 [luteinization] GO:0001666 [response to hypoxia] GO:0001779 [natural killer cell differentiation] GO:0001889 [liver development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006101 [citrate metabolic process] GO:0006103 [2-oxoglutarate metabolic process] GO:0006105 [succinate metabolic process] GO:0006107 [oxaloacetate metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006549 [isoleucine metabolic process] GO:0006573 [valine metabolic process] GO:0006600 [creatine metabolic process] GO:0006631 [fatty acid metabolic process] GO:0006953 [acute-phase response] GO:0007165 [signal transduction] GO:0007259 [JAK-STAT cascade] GO:0007548 [sex differentiation] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0008284 [positive regulation of cell proliferation] GO:0019218 [regulation of steroid metabolic process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019530 [taurine metabolic process] GO:0019903 [protein phosphatase binding] GO:0019915 [lipid storage] GO:0030155 [regulation of cell adhesion] GO:0030856 [regulation of epithelial cell differentiation] GO:0032355 [response to estradiol] GO:0032496 [response to lipopolysaccharide] GO:0032819 [positive regulation of natural killer cell proliferation] GO:0032825 [positive regulation of natural killer cell differentiation] GO:0032870 [cellular response to hormone stimulus] GO:0033077 [T cell differentiation in thymus] GO:0035259 [glucocorticoid receptor binding] GO:0038161 [prolactin signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0040018 [positive regulation of multicellular organism growth] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042448 [progesterone metabolic process] GO:0043029 [T cell homeostasis] GO:0043066 [negative regulation of apoptotic process] GO:0043434 [response to peptide hormone] GO:0043565 [sequence-specific DNA binding] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045471 [response to ethanol] GO:0045579 [positive regulation of B cell differentiation] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045621 [positive regulation of lymphocyte differentiation] GO:0045647 [negative regulation of erythrocyte differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0046449 [creatinine metabolic process] GO:0046543 [development of secondary female sexual characteristics] GO:0046544 [development of secondary male sexual characteristics] GO:0046983 [protein dimerization activity] GO:0048541 [Peyer's patch development] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050729 [positive regulation of inflammatory response] GO:0051272 [positive regulation of cellular component movement] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070669 [response to interleukin-2] GO:0070670 [response to interleukin-4] GO:0070672 [response to interleukin-15] GO:0071363 [cellular response to growth factor stimulus] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0097531 [mast cell migration]
C9J4I3 [Direct mapping] Signal transducer and activator of transcription 5B
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)