Expression of CD7 in cancer - Summary - The Human Protein Atlas

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CD7

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD7
Gene description	CD7 molecule
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (Hep G2, MOLT-4)
HPA (normal tissue):	Tissue enhanced (appendix, lymph node, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA039079 , CAB002594
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), melanoma (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Melanoma p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039079	CAB002594

GENE INFORMATION
Gene name	CD7 (HGNC Symbol)
Synonyms	GP40, LEU-9, Tp40, TP41
Description	CD7 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	82314868 - 82317602
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173762 (version 83.38)
Entrez gene	924
UniProt	P09564 (UniProt - Evidence at protein level)
neXtProt	NX_P09564
Antibodypedia	CD7 antibodies

PROTEIN BROWSER

CD7-001	CD7-002	CD7-003	CD7-005	CD7-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD7-001 ENSP00000312027 ENST00000312648	P09564 [Direct mapping] T-cell antigen CD7 Q29VG3 [Target identity:100%; Query identity:100%] CD7 antigen; CD7 antigen (P41), isoform CRA_c Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042110 [T cell activation] GO:0048873 [homeostasis of number of cells within a tissue] GO:0070062 [extracellular exosome] Show all	240 aa 25.4 kDa	Yes	1
CD7-002 ENSP00000463612 ENST00000584284	J3QLM0 [Direct mapping] T-cell antigen CD7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	221 aa 23 kDa	Yes	1
CD7-003 ENSP00000463489 ENST00000583376	J3QLC7 [Direct mapping] T-cell antigen CD7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	140 aa 14.8 kDa	No	1
CD7-005 ENSP00000464182 ENST00000582480	J3QRF1 [Direct mapping] T-cell antigen CD7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 17.2 kDa	Yes	0
CD7-006 ENSP00000464565 ENST00000578509	J3QS78 [Direct mapping] T-cell antigen CD7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	121 aa 12.4 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.