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Thyroid cancers showed moderate cytoplasmic staining while cases of hepatocellular, prostate and testicular cancers showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
A few cases of colorectal, ovarian, endometrial, lung, urothelial, gastric and pancreatic cancers showed moderate cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
TCAP (HGNC Symbol)
Synonyms
CMD1N, LGMD2G, T-cap, TELE, telethonin
Description
Titin-cap (HGNC Symbol)
Entrez gene summary
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]