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CCS

GENERAL INFORMATION

Gene name

 CCS

Gene description

 Copper chaperone for superoxide dismutase

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA040026 , HPA044090 , CAB008672
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CCS

Synonyms

Description

 Copper chaperone for superoxide dismutase (HGNC Symbol)

Entrez gene summary

 Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 66592821 - 66606019

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173992 (version 83.38)

Entrez gene

 9973

UniProt

 O14618 (UniProt - Evidence at protein level)

neXtProt

 NX_O14618

Antibodypedia

 CCS antibodies

PROTEIN BROWSER
CCS-001
CCS-007
CCS-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCS-001
ENSP00000436318
ENST00000533244
O14618 [Direct mapping]
Copper chaperone for superoxide dismutase
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004784 [superoxide dismutase activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006801 [superoxide metabolic process]
GO:0008270 [zinc ion binding]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015680 [intracellular copper ion transport]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0019430 [removal of superoxide radicals]
GO:0030001 [metal ion transport]
GO:0035434 [copper ion transmembrane transport]
GO:0046872 [metal ion binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 274 aa
29 kDa 		No 0
CCS-007
ENSP00000436379
ENST00000534763
E9PP76 [Direct mapping]
Superoxide dismutase [Cu-Zn]
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004784 [superoxide dismutase activity]
GO:0006801 [superoxide metabolic process]
GO:0008270 [zinc ion binding]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0019430 [removal of superoxide radicals]
GO:0043085 [positive regulation of catalytic activity]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
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 68 aa
7.3 kDa 		No 0
CCS-009
ENSP00000307870
ENST00000310190
J3KNF4 [Direct mapping]
Copper chaperone for superoxide dismutase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004784 [superoxide dismutase activity]
GO:0006801 [superoxide metabolic process]
GO:0008270 [zinc ion binding]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0019430 [removal of superoxide radicals]
GO:0030001 [metal ion transport]
GO:0043085 [positive regulation of catalytic activity]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 255 aa
27.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.