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ADCY6

GENERAL INFORMATION

Gene name

 ADCY6

Gene description

 Adenylate cyclase 6

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB018365
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB018365

GENE INFORMATION

Gene name

 ADCY6 (HGNC Symbol)

Synonyms

 AC6

Description

 Adenylate cyclase 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 48766194 - 48789037

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174233 (version 83.38)

Entrez gene

 112

UniProt

 O43306 (UniProt - Evidence at protein level)

neXtProt

 NX_O43306

Antibodypedia

 ADCY6 antibodies

PROTEIN BROWSER
ADCY6-002
ADCY6-003
ADCY6-009
ADCY6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADCY6-002
ENSP00000311405
ENST00000307885
O43306 [Direct mapping]
Adenylate cyclase type 6
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Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008294 [calcium- and calmodulin-responsive adenylate cyclase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019901 [protein kinase binding]
GO:0019933 [cAMP-mediated signaling]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031528 [microvillus membrane]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0035811 [negative regulation of urine volume]
GO:0042312 [regulation of vasodilation]
GO:0042383 [sarcolemma]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0097110 [scaffold protein binding]
GO:1904117 [cellular response to vasopressin]
GO:1904322 [cellular response to forskolin]
Show all
 1168 aa
130.6 kDa 		No >9
ADCY6-003
ENSP00000446730
ENST00000550422
O43306 [Direct mapping]
Adenylate cyclase type 6
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019901 [protein kinase binding]
GO:0019933 [cAMP-mediated signaling]
GO:0031226 [intrinsic component of plasma membrane]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0035811 [negative regulation of urine volume]
GO:0042312 [regulation of vasodilation]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:1904117 [cellular response to vasopressin]
GO:1904322 [cellular response to forskolin]
Show all
 1115 aa
124.9 kDa 		No >9
ADCY6-009
ENSP00000447702
ENST00000548820
F8VZJ5 [Direct mapping]
Adenylate cyclase type 6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 83 aa
9.6 kDa 		No 0
ADCY6-201
ENSP00000350536
ENST00000357869
O43306 [Direct mapping]
Adenylate cyclase type 6
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019901 [protein kinase binding]
GO:0019933 [cAMP-mediated signaling]
GO:0031226 [intrinsic component of plasma membrane]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0035811 [negative regulation of urine volume]
GO:0042312 [regulation of vasodilation]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:1904117 [cellular response to vasopressin]
GO:1904322 [cellular response to forskolin]
Show all
 1115 aa
124.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.