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SLC6A19

GENERAL INFORMATION

Gene name

 SLC6A19

Gene description

 Solute carrier family 6 (neutral amino acid transporter), member 19

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, kidney, small intestine)
GTEx:Tissue enriched (small intestine)
FANTOM5:Tissue enhanced (colon, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective membranous expression in intestine, renal tubules and gallbladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA037415 , HPA043207
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, kidney, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)

GENE INFORMATION

Gene name

 SLC6A19

Synonyms

Description

 Solute carrier family 6 (neutral amino acid transporter), member 19 (HGNC Symbol)

Entrez gene summary

 This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p15.33

Chromosome location (bp)

 1201595 - 1225117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174358 (version 83.38)

Entrez gene

 340024

UniProt

 Q695T7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q695T7

Antibodypedia

 SLC6A19 antibodies

PROTEIN BROWSER
SLC6A19-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC6A19-001
ENSP00000305302
ENST00000304460
Q695T7 [Direct mapping]
Sodium-dependent neutral amino acid transporter B(0)AT1
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0003333 [amino acid transmembrane transport]
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0006865 [amino acid transport]
GO:0007584 [response to nutrient]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015804 [neutral amino acid transport]
GO:0016021 [integral component of membrane]
GO:0031526 [brush border membrane]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 634 aa
71.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.