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ATP2A2

GENERAL INFORMATION

Gene name

 ATP2A2

Gene description

 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in skeletal and heart muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA062605
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA062605

GENE INFORMATION

Gene name

 ATP2A2 (HGNC Symbol)

Synonyms

 ATP2B, DAR, SERCA2

Description

 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 110280756 - 110351093

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174437 (version 83.38)

Entrez gene

 488

UniProt

 P16615 (UniProt - Evidence at protein level)

neXtProt

 NX_P16615

Antibodypedia

 ATP2A2 antibodies

PROTEIN BROWSER
ATP2A2-001
ATP2A2-003
ATP2A2-004
ATP2A2-006
ATP2A2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP2A2-001
ENSP00000311186
ENST00000308664
P16615 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0010460 [positive regulation of heart rate]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014801 [longitudinal sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0019899 [enzyme binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0044548 [S100 protein binding]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0086039 [calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential]
GO:0090534 [calcium ion-transporting ATPase complex]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1903515 [calcium ion transport from cytosol to endoplasmic reticulum]
GO:1990036 [calcium ion import into sarcoplasmic reticulum]
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 997 aa
109.7 kDa 		No >9
ATP2A2-003
ENSP00000440045
ENST00000539276
P16615 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002026 [regulation of the force of heart contraction]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006984 [ER-nucleus signaling pathway]
GO:0006996 [organelle organization]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0010460 [positive regulation of heart rate]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0012506 [vesicle membrane]
GO:0014704 [intercalated disc]
GO:0014801 [longitudinal sarcoplasmic reticulum]
GO:0014883 [transition between fast and slow fiber]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0019899 [enzyme binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031775 [lutropin-choriogonadotropic hormone receptor binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033292 [T-tubule organization]
GO:0034220 [ion transmembrane transport]
GO:0034599 [cellular response to oxidative stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043234 [protein complex]
GO:0043434 [response to peptide hormone]
GO:0044548 [S100 protein binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0086039 [calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential]
GO:0090534 [calcium ion-transporting ATPase complex]
GO:0097470 [ribbon synapse]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1903233 [regulation of calcium ion-dependent exocytosis of neurotransmitter]
GO:1903515 [calcium ion transport from cytosol to endoplasmic reticulum]
GO:1990036 [calcium ion import into sarcoplasmic reticulum]
Show all
 1042 aa
114.8 kDa 		No >9
ATP2A2-004
ENSP00000447406
ENST00000552636
F8W1Z7 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 44 aa
5.3 kDa 		No 0
ATP2A2-006
ENSP00000449454
ENST00000548169
H7C5W9 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0046872 [metal ion binding]
GO:0070588 [calcium ion transmembrane transport]
Show all
 933 aa
102.5 kDa 		No 9
ATP2A2-012
ENSP00000450407
ENST00000553144
A0A0C4DH86 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 46 aa
5.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.