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CNTNAP2

GENERAL INFORMATION

Gene name

 CNTNAP2

Gene description

 Contactin associated protein-like 2

Protein class

 Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (prostate cancer)
HPA (cell line):Cell line enhanced (AF22, NTERA-2, SCLC-21H)
HPA (normal tissue):Group enriched (cerebral cortex, prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA002739
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA002739

GENE INFORMATION

Gene name

 CNTNAP2 (HGNC Symbol)

Synonyms

 Caspr2, KIAA0868, NRXN4

Description

 Contactin associated protein-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]

Chromosome

 7

Cytoband

Chromosome location (bp)

 146116002 - 148420998

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174469 (version 83.38)

Entrez gene

 26047

UniProt

 Q9UHC6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHC6

Antibodypedia

 CNTNAP2 antibodies

PROTEIN BROWSER
CNTNAP2-001
CNTNAP2-003
CNTNAP2-005
CNTNAP2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNTNAP2-001
ENSP00000354778
ENST00000361727
Q9UHC6 [Direct mapping]
Contactin-associated protein-like 2
A0A090N7T7 [Target identity:100%; Query identity:100%]
Contactin associated protein-like 2; Contactin associated protein-like 2, isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0007155 [cell adhesion]
GO:0007420 [brain development]
GO:0007612 [learning]
GO:0008038 [neuron recognition]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019226 [transmission of nerve impulse]
GO:0019899 [enzyme binding]
GO:0021756 [striatum development]
GO:0021761 [limbic system development]
GO:0021794 [thalamus development]
GO:0021987 [cerebral cortex development]
GO:0030534 [adult behavior]
GO:0030673 [axolemma]
GO:0031175 [neuron projection development]
GO:0035176 [social behavior]
GO:0042297 [vocal learning]
GO:0044224 [juxtaparanode region of axon]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0071109 [superior temporal gyrus development]
GO:0071205 [protein localization to juxtaparanode region of axon]
GO:0071625 [vocalization behavior]
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 1331 aa
148.2 kDa 		Yes 1
CNTNAP2-003
ENSP00000486292
ENST00000463592
Q9UHC6 [Direct mapping]
Contactin-associated protein-like 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0007155 [cell adhesion]
GO:0007420 [brain development]
GO:0007612 [learning]
GO:0008038 [neuron recognition]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019226 [transmission of nerve impulse]
GO:0019899 [enzyme binding]
GO:0021756 [striatum development]
GO:0021761 [limbic system development]
GO:0021794 [thalamus development]
GO:0021987 [cerebral cortex development]
GO:0030534 [adult behavior]
GO:0030673 [axolemma]
GO:0031175 [neuron projection development]
GO:0035176 [social behavior]
GO:0042297 [vocal learning]
GO:0044224 [juxtaparanode region of axon]
GO:0045163 [clustering of voltage-gated potassium channels]
GO:0071109 [superior temporal gyrus development]
GO:0071205 [protein localization to juxtaparanode region of axon]
GO:0071625 [vocalization behavior]
Show all
 108 aa
11.9 kDa 		No 1
CNTNAP2-005
ENSP00000487516
ENST00000628930
B7Z1Y6 [Direct mapping]
Contactin-associated protein-like 2; cDNA FLJ53861, highly similar to Contactin-associated protein-like 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
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 390 aa
43 kDa 		No 1
CNTNAP2-006
ENSP00000485955
ENST00000625365
A0A0D9SES4 [Direct mapping]
Contactin-associated protein-like 2
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 120 aa
12.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.