Expression of UGT8 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

UGT8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UGT8
Gene description	UDP glycosyltransferase 8
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, RPTEC TERT1, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA014405
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014405

GENE INFORMATION
Gene name	UGT8 (HGNC Symbol)
Synonyms	CGT
Description	UDP glycosyltransferase 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	4
Cytoband	q26
Chromosome location (bp)	114598455 - 114678224
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174607 (version 83.38)
Entrez gene	7368
UniProt	Q16880 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16880
Antibodypedia	UGT8 antibodies

PROTEIN BROWSER

UGT8-001	UGT8-002	UGT8-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UGT8-001 ENSP00000311648 ENST00000310836	Q16880 [Direct mapping] 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002175 [protein localization to paranode region of axon] GO:0003851 [2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity] GO:0006682 [galactosylceramide biosynthetic process] GO:0007010 [cytoskeleton organization] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0008489 [UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0030913 [paranodal junction assembly] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0048812 [neuron projection morphogenesis] GO:0052696 [flavonoid glucuronidation] Show all	541 aa 61.4 kDa	Yes	1
UGT8-002 ENSP00000378019 ENST00000394511	Q16880 [Direct mapping] 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003851 [2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity] GO:0006682 [galactosylceramide biosynthetic process] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	541 aa 61.4 kDa	Yes	1
UGT8-003 ENSP00000421446 ENST00000507710	D6RFW2 [Direct mapping] 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	141 aa 16 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.