Tissue expression of UGT8 - Summary - The Human Protein Atlas

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UGT8

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	UGT8
Gene description	UDP glycosyltransferase 8
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (hippocampus)
FANTOM5:	Tissue enhanced (brain, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, most abundant in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA014405
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION
Gene name	UGT8 (HGNC Symbol)
Synonyms	CGT
Description	UDP glycosyltransferase 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	4
Cytoband	q26
Chromosome location (bp)	114598455 - 114678224
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174607 (version 83.38)
Entrez gene	7368
UniProt	Q16880 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16880
Antibodypedia	UGT8 antibodies

PROTEIN BROWSER

UGT8-001	UGT8-002	UGT8-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UGT8-001 ENSP00000311648 ENST00000310836	Q16880 [Direct mapping] 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002175 [protein localization to paranode region of axon] GO:0003851 [2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity] GO:0006682 [galactosylceramide biosynthetic process] GO:0007010 [cytoskeleton organization] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0008489 [UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0030913 [paranodal junction assembly] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0048812 [neuron projection morphogenesis] GO:0052696 [flavonoid glucuronidation] Show all	541 aa 61.4 kDa	Yes	1
UGT8-002 ENSP00000378019 ENST00000394511	Q16880 [Direct mapping] 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003851 [2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity] GO:0006682 [galactosylceramide biosynthetic process] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	541 aa 61.4 kDa	Yes	1
UGT8-003 ENSP00000421446 ENST00000507710	D6RFW2 [Direct mapping] 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	141 aa 16 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.