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NLRP6

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GENERAL INFORMATION

Gene name

 NLRP6

Gene description

 NLR family, pyrin domain containing 6

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-266/70, REH)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, REH)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NLRP6 (HGNC Symbol)

Synonyms

 CLR11.4, NALP6, PAN3, PYPAF5

Description

 NLR family, pyrin domain containing 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 278365 - 285359

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174885 (version 83.38)

Entrez gene

 171389

UniProt

 P59044 (UniProt - Evidence at protein level)

neXtProt

 NX_P59044

Antibodypedia

 NLRP6 antibodies

PROTEIN BROWSER
NLRP6-001
NLRP6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLRP6-001
ENSP00000309767
ENST00000312165
P59044 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 6
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0005000 [vasopressin receptor activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009617 [response to bacterium]
GO:0010506 [regulation of autophagy]
GO:0031965 [nuclear membrane]
GO:0034122 [negative regulation of toll-like receptor signaling pathway]
GO:0042060 [wound healing]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043409 [negative regulation of MAPK cascade]
GO:0050727 [regulation of inflammatory response]
GO:0050777 [negative regulation of immune response]
GO:0070255 [regulation of mucus secretion]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
Show all
 892 aa
98.8 kDa 		No 0
NLRP6-002
ENSP00000433617
ENST00000534750
P59044 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 6
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005000 [vasopressin receptor activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0031965 [nuclear membrane]
GO:0050727 [regulation of inflammatory response]
Show all
 891 aa
98.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.