Expression of NLRP6 in cancer - Summary - The Human Protein Atlas

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NLRP6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NLRP6
Gene description	NLR family, pyrin domain containing 6
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (REH, U-266/70)
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic positivity in small intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA043681 , HPA048500
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043681	HPA048500

GENE INFORMATION
Gene name	NLRP6 (HGNC Symbol)
Synonyms	CLR11.4, NALP6, PAN3, PYPAF5
Description	NLR family, pyrin domain containing 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	278365 - 285359
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174885 (version 83.38)
Entrez gene	171389
UniProt	P59044 (UniProt - Evidence at protein level)
neXtProt	NX_P59044
Antibodypedia	NLRP6 antibodies

PROTEIN BROWSER

NLRP6-001	NLRP6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLRP6-001 ENSP00000309767 ENST00000312165	P59044 [Direct mapping] NACHT, LRR and PYD domains-containing protein 6 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002862 [negative regulation of inflammatory response to antigenic stimulus] GO:0005000 [vasopressin receptor activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009617 [response to bacterium] GO:0010506 [regulation of autophagy] GO:0031965 [nuclear membrane] GO:0034122 [negative regulation of toll-like receptor signaling pathway] GO:0042060 [wound healing] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043409 [negative regulation of MAPK cascade] GO:0050727 [regulation of inflammatory response] GO:0050777 [negative regulation of immune response] GO:0070255 [regulation of mucus secretion] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] Show all	892 aa 98.8 kDa	No	0
NLRP6-002 ENSP00000433617 ENST00000534750	P59044 [Direct mapping] NACHT, LRR and PYD domains-containing protein 6 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005000 [vasopressin receptor activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0031965 [nuclear membrane] GO:0050727 [regulation of inflammatory response] Show all	891 aa 98.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.