Expression of NDUFA11 in cancer - Summary - The Human Protein Atlas

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NDUFA11

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	NDUFA11
Gene description	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and cervical cancer (favourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	NDUFA11 (HGNC Symbol)
Synonyms	B14.7
Description	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	5891276 - 5904006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174886 (version 83.38)
Entrez gene	126328
UniProt	Q86Y39 (UniProt - Evidence at protein level)
neXtProt	NX_Q86Y39
Antibodypedia	NDUFA11 antibodies

PROTEIN BROWSER

NDUFA11-001	NDUFA11-002	NDUFA11-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFA11-001 ENSP00000389160 ENST00000418389	Q86Y39 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	228 aa 23.4 kDa	No	0
NDUFA11-002 ENSP00000311740 ENST00000308961	Q86Y39 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	141 aa 14.9 kDa	No	3
NDUFA11-004 ENSP00000467706 ENST00000592634	K7EQ77 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	120 aa 12.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.