Fields »
ABOUT
HELP
BLOG
KCTD13

GENERAL INFORMATION

Gene name

 KCTD13

Gene description

 Potassium channel tetramerization domain containing 13

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA043524
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), colorectal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043524

GENE INFORMATION

Gene name

 KCTD13 (HGNC Symbol)

Synonyms

 FKSG86, PDIP1, POLDIP1

Description

 Potassium channel tetramerization domain containing 13 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 29905012 - 29927035

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174943 (version 83.38)

Entrez gene

 253980

UniProt

 Q8WZ19 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WZ19

Antibodypedia

 KCTD13 antibodies

PROTEIN BROWSER
KCTD13-001
KCTD13-003
KCTD13-004
KCTD13-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCTD13-001
ENSP00000455785
ENST00000568000
Q8WZ19 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0017049 [GTP-Rho binding]
GO:0019904 [protein domain specific binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0042802 [identical protein binding]
GO:0043149 [stress fiber assembly]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045740 [positive regulation of DNA replication]
GO:0051260 [protein homooligomerization]
Show all
 329 aa
36.4 kDa 		No 0
KCTD13-003
ENSP00000458486
ENST00000561540
I3L108 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0051260 [protein homooligomerization]
Show all
 209 aa
22.3 kDa 		No 0
KCTD13-004
ENSP00000460526
ENST00000566413
I3L3K4 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Show all
Predicted intracellular proteins
Show all
 81 aa
9 kDa 		No 0
KCTD13-009
ENSP00000454282
ENST00000568995
H3BM90 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Show all
Predicted intracellular proteins
Show all
 140 aa
15.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.