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FUT1

GENERAL INFORMATION

Gene name

 FUT1

Gene description

 Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)

Protein class

 Blood group antigen proteins
Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL, SCLC-21H)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 FUT1 (HGNC Symbol)

Synonyms

 H, HSC

Description

 Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48748011 - 48755390

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000174951 (version 83.38)

Entrez gene

 2523

UniProt

 P19526 (UniProt - Evidence at transcript level)

neXtProt

 NX_P19526

Antibodypedia

 FUT1 antibodies

PROTEIN BROWSER
FUT1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FUT1-001
ENSP00000312021
ENST00000310160
P19526 [Direct mapping]
Galactoside 2-alpha-L-fucosyltransferase 1
Q6IZA2 [Target identity:100%; Query identity:100%]
Alpha(1,2) fucosyltransferase 1; Alpha(1,2)fucosyltransferase; Fucosyltransferase; HCG16221
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Enzymes
   ENZYME proteins
   Transferases
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0005794 [Golgi apparatus]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006486 [protein glycosylation]
GO:0008107 [galactoside 2-alpha-L-fucosyltransferase activity]
GO:0008417 [fucosyltransferase activity]
GO:0016020 [membrane]
GO:0032580 [Golgi cisterna membrane]
GO:0036065 [fucosylation]
GO:0042355 [L-fucose catabolic process]
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 365 aa
41.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.