Tissue expression of MRPS22 - Summary - The Human Protein Atlas

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MRPS22

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MRPS22
Gene description	Mitochondrial ribosomal protein S22
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA006083 , HPA007830
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MRPS22 (HGNC Symbol)
Synonyms	C3orf5, GIBT, GK002, MRP-S22
Description	Mitochondrial ribosomal protein S22 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q23
Chromosome location (bp)	139005806 - 139357223
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175110 (version 83.38)
Entrez gene	56945
UniProt	P82650 (UniProt - Evidence at protein level)
neXtProt	NX_P82650
Antibodypedia	MRPS22 antibodies

PROTEIN BROWSER

MRPS22-001	MRPS22-005	MRPS22-007	MRPS22-008	MRPS22-012	MRPS22-014	MRPS22-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS22-001 ENSP00000418008 ENST00000495075	P82650 [Direct mapping] 28S ribosomal protein S22, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005763 [mitochondrial small ribosomal subunit] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	360 aa 41.3 kDa	Yes	0
MRPS22-005 ENSP00000418233 ENST00000465056	G5E9V5 [Direct mapping] 28S ribosomal protein S22, mitochondrial; Mitochondrial ribosomal protein S22, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005840 [ribosome] Show all	359 aa 41.2 kDa	Yes	0
MRPS22-007 ENSP00000419303 ENST00000478464	G5E9W7 [Direct mapping] 28S ribosomal protein S22, mitochondrial; Mitochondrial ribosomal protein S22, isoform CRA_e Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005840 [ribosome] Show all	319 aa 36.8 kDa	No	0
MRPS22-008 ENSP00000419920 ENST00000465373	H7C5H3 [Direct mapping] 28S ribosomal protein S22, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	200 aa 22.8 kDa	No	0
MRPS22-012 ENSP00000420229 ENST00000480644	H7C5L9 [Direct mapping] 28S ribosomal protein S22, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 14.6 kDa	No	0
MRPS22-014 ENSP00000417104 ENST00000495225	C9J5D8 [Direct mapping] 28S ribosomal protein S22, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.6 kDa	No	0
MRPS22-201 ENSP00000310785 ENST00000310776	P82650 [Direct mapping] 28S ribosomal protein S22, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005763 [mitochondrial small ribosomal subunit] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	360 aa 41.3 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.