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CADM2

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GENERAL INFORMATION

Gene name

 CADM2

Gene description

 Cell adhesion molecule 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (AN3-CA, AF22)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CADM2 (HGNC Symbol)

Synonyms

 IGSF4D, Necl-3, NECL3, SynCAM2

Description

 Cell adhesion molecule 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 3

Cytoband

 p12.1

Chromosome location (bp)

 84958981 - 86074429

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175161 (version 83.38)

Entrez gene

 253559

UniProt

 Q8N3J6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N3J6

Antibodypedia

 CADM2 antibodies

PROTEIN BROWSER
CADM2-001
CADM2-002
CADM2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CADM2-001
ENSP00000384193
ENST00000405615
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
 437 aa
47.6 kDa 		Yes 1
CADM2-002
ENSP00000373200
ENST00000383699
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
G3XHN4 [Target identity:100%; Query identity:100%]
Cell adhesion molecule 2 isoform 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
 404 aa
44.4 kDa 		Yes 1
CADM2-006
ENSP00000384575
ENST00000407528
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
 435 aa
47.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.