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CADM2

GENERAL INFORMATION

Gene name

 CADM2

Gene description

 Cell adhesion molecule 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (AF22, AN3-CA)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in CNS and peripheral nerve fibers.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA010024
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA010024

GENE INFORMATION

Gene name

 CADM2 (HGNC Symbol)

Synonyms

 IGSF4D, Necl-3, NECL3, SynCAM2

Description

 Cell adhesion molecule 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 3

Cytoband

 p12.1

Chromosome location (bp)

 84958981 - 86074429

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175161 (version 83.38)

Entrez gene

 253559

UniProt

 Q8N3J6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N3J6

Antibodypedia

 CADM2 antibodies

PROTEIN BROWSER
CADM2-001
CADM2-002
CADM2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CADM2-001
ENSP00000384193
ENST00000405615
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
 437 aa
47.6 kDa 		Yes 1
CADM2-002
ENSP00000373200
ENST00000383699
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
G3XHN4 [Target identity:100%; Query identity:100%]
Cell adhesion molecule 2 isoform 4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
 404 aa
44.4 kDa 		Yes 1
CADM2-006
ENSP00000384575
ENST00000407528
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
 435 aa
47.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.