Cell atlas - MED16 - The Human Protein Atlas

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MED16

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	MED16
Gene description	Mediator complex subunit 16
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046495
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046495	MCF7	Nucleoli
	HPA046495	U-2 OS	No staining
	HPA046495	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	MED16 (HGNC Symbol)
Synonyms	DRIP92, THRAP5, TRAP95
Description	Mediator complex subunit 16 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	867630 - 893218
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175221 (version 83.38)
Entrez gene	10025
UniProt	Q9Y2X0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2X0
Antibodypedia	MED16 antibodies

PROTEIN BROWSER

MED16-001	MED16-002	MED16-003	MED16-004	MED16-005	MED16-006	MED16-011	MED16-021	MED16-039	MED16-201	MED16-202	MED16-203	MED16-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED16-001 ENSP00000379153 ENST00000395808	Q9Y2X0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003824 [catalytic activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016592 [mediator complex] GO:0030375 [thyroid hormone receptor coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0042809 [vitamin D receptor binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046966 [thyroid hormone receptor binding] GO:2000273 [positive regulation of receptor activity] Show all	841 aa 93 kDa	No	0
MED16-002 ENSP00000480766 ENST00000606828	B9TX03 [Direct mapping] Mediator complex subunit MED16 variant MED16_i10; Mediator of RNA polymerase II transcription subunit 16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	194 aa 21.9 kDa	No	0
MED16-003 ENSP00000308528 ENST00000312090	Q9Y2X0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003824 [catalytic activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016592 [mediator complex] GO:0030375 [thyroid hormone receptor coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0042809 [vitamin D receptor binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046966 [thyroid hormone receptor binding] GO:2000273 [positive regulation of receptor activity] Show all	860 aa 95 kDa	No	0
MED16-004 ENSP00000465827 ENST00000586342	K7EKX6 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.5 kDa	No	0
MED16-005 ENSP00000466868 ENST00000592943	B9TWZ6 [Direct mapping] Mediator complex subunit MED16 variant MED16_i3; Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0008152 [metabolic process] Show all	537 aa 58.9 kDa	No	0
MED16-006 ENSP00000464810 ENST00000589119	Q9Y2X0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003824 [catalytic activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016592 [mediator complex] GO:0030375 [thyroid hormone receptor coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0042809 [vitamin D receptor binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046966 [thyroid hormone receptor binding] GO:2000273 [positive regulation of receptor activity] Show all	877 aa 96.8 kDa	No	0
MED16-011 ENSP00000465762 ENST00000586017	K7EKS6 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	462 aa 51.5 kDa	No	0
MED16-021 ENSP00000475725 ENST00000607471	U3KQB4 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		505 aa 55.4 kDa	No	0
MED16-039 ENSP00000478286 ENST00000621073	A0A087WU12 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.6 kDa	No	0
MED16-201 ENSP00000269814 ENST00000269814	B9TX12 [Direct mapping] Mediator complex subunit MED16 variant MED16_i19; Mediator of RNA polymerase II transcription subunit 16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	218 aa 24.5 kDa	No	0
MED16-202 ENSP00000325612 ENST00000325464	Q9Y2X0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003824 [catalytic activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016592 [mediator complex] GO:0030375 [thyroid hormone receptor coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0042809 [vitamin D receptor binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046966 [thyroid hormone receptor binding] GO:2000273 [positive regulation of receptor activity] Show all	877 aa 96.8 kDa	No	0
MED16-203 ENSP00000479411 ENST00000616387	B9TX11 [Direct mapping] Mediator complex subunit MED16 variant MED16_i18; Mediator of RNA polymerase II transcription subunit 16 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	219 aa 24.1 kDa	No	0
MED16-204 ENSP00000483533 ENST00000617672	B9TX21 [Direct mapping] Mediator complex subunit MED16 variant MED16_i28; Mediator of RNA polymerase II transcription subunit 16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 14.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.