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CATSPER1

GENERAL INFORMATION

Gene name

 CATSPER1

Gene description

 Cation channel, sperm associated 1

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CAPAN-2, EFO-21, HMC-1, LHCN-M2)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CATSPER1 (HGNC Symbol)

Synonyms

 CATSPER

Description

 Cation channel, sperm associated 1 (HGNC Symbol)

Entrez gene summary

 Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 66016752 - 66026517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175294 (version 83.38)

Entrez gene

 117144

UniProt

 Q8NEC5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NEC5

Antibodypedia

 CATSPER1 antibodies

PROTEIN BROWSER
CATSPER1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CATSPER1-001
ENSP00000309052
ENST00000312106
Q8NEC5 [Direct mapping]
Cation channel sperm-associated protein 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
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GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0007342 [fusion of sperm to egg plasma membrane]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0030317 [sperm motility]
GO:0031514 [motile cilium]
GO:0032504 [multicellular organism reproduction]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035036 [sperm-egg recognition]
GO:0036128 [CatSper complex]
GO:0051924 [regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0060296 [regulation of cilium beat frequency involved in ciliary motility]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
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 780 aa
90.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.