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ISX

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GENERAL INFORMATION

Gene name

 ISX

Gene description

 Intestine-specific homeobox

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

RNA cell category

 Group enriched (Hep G2, CACO-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA060328
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, CACO-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

 Nucleoplasm (supported)

Additional location

 Nuclear bodies (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA060328 CACO-2 Nucleoplasm
Nuclear bodies
HPA060328 Hep G2 Nucleoplasm
Nuclear bodies
HPA060328 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 ISX (HGNC Symbol)

Synonyms

 RAXLX

Description

 Intestine-specific homeobox (HGNC Symbol)

Entrez gene summary

 Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 35066136 - 35087387

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175329 (version 83.38)

Entrez gene

 91464

UniProt

 Q2M1V0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q2M1V0

Antibodypedia

 ISX antibodies

PROTEIN BROWSER
ISX-001
ISX-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ISX-001
ENSP00000311492
ENST00000308700
Q2M1V0 [Direct mapping]
Intestine-specific homeobox
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:1901738 [regulation of vitamin A metabolic process]
GO:1904479 [negative regulation of intestinal absorption]
Show all
 245 aa
27 kDa 		No 0
ISX-002
ENSP00000386037
ENST00000404699
Q2M1V0 [Direct mapping]
Intestine-specific homeobox
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 245 aa
27 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.