Expression of ISX in cancer - Summary - The Human Protein Atlas

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ISX

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ISX
Gene description	Intestine-specific homeobox
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Group enriched (CACO-2, Hep G2)
HPA (normal tissue):	Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Paneth cell expression in intestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA060328
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060328

GENE INFORMATION
Gene name	ISX (HGNC Symbol)
Synonyms	RAXLX
Description	Intestine-specific homeobox (HGNC Symbol)
Entrez gene summary	Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	35066136 - 35087387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175329 (version 83.38)
Entrez gene	91464
UniProt	Q2M1V0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2M1V0
Antibodypedia	ISX antibodies

PROTEIN BROWSER

ISX-001	ISX-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ISX-001 ENSP00000311492 ENST00000308700	Q2M1V0 [Direct mapping] Intestine-specific homeobox Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:1901738 [regulation of vitamin A metabolic process] GO:1904479 [negative regulation of intestinal absorption] Show all	245 aa 27 kDa	No	0
ISX-002 ENSP00000386037 ENST00000404699	Q2M1V0 [Direct mapping] Intestine-specific homeobox Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	245 aa 27 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.