Cell atlas - RMI2 - The Human Protein Atlas

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RMI2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RMI2
Gene description	RecQ mediated genome instability 2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA040995
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the cytosol.

Main location

Nuclear speckles (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040995	A-431	Nuclear speckles
	HPA040995	A-431	Cytosol
	HPA040995	U-2 OS	Nuclear speckles
	HPA040995	U-2 OS	Cytosol
	HPA040995	U-251 MG	Nuclear speckles
	HPA040995	U-251 MG	Cytosol

GENE INFORMATION
Gene name	RMI2 (HGNC Symbol)
Synonyms	BLAP18, C16orf75, MGC24665
Description	RecQ mediated genome instability 2 (HGNC Symbol)
Entrez gene summary	RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]
Chromosome	16
Cytoband	p13.13
Chromosome location (bp)	11249619 - 11351762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175643 (version 83.38)
Entrez gene	116028
UniProt	Q96E14 (UniProt - Evidence at protein level)
neXtProt	NX_Q96E14
Antibodypedia	RMI2 antibodies

PROTEIN BROWSER

RMI2-001	RMI2-002	RMI2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RMI2-001 ENSP00000310356 ENST00000312499	Q96E14 [Direct mapping] RecQ-mediated genome instability protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0045003 [double-strand break repair via synthesis-dependent strand annealing] Show all	147 aa 15.9 kDa	No	0
RMI2-002 ENSP00000461206 ENST00000572173	Q96E14 [Direct mapping] RecQ-mediated genome instability protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0045003 [double-strand break repair via synthesis-dependent strand annealing] Show all	84 aa 9.3 kDa	No	0
RMI2-005 ENSP00000459601 ENST00000576027	I3L2E0 [Direct mapping] RecQ-mediated genome instability protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		27 aa 2.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.