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RMI2

GENERAL INFORMATION

Gene name

 RMI2

Gene description

 RecQ mediated genome instability 2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040995
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and cervical cancer (favourable).
Liver cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040995

GENE INFORMATION

Gene name

 RMI2 (HGNC Symbol)

Synonyms

 BLAP18, C16orf75, MGC24665

Description

 RecQ mediated genome instability 2 (HGNC Symbol)

Entrez gene summary

 RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]

Chromosome

 16

Cytoband

 p13.13

Chromosome location (bp)

 11249619 - 11351762

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175643 (version 83.38)

Entrez gene

 116028

UniProt

 Q96E14 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96E14

Antibodypedia

 RMI2 antibodies

PROTEIN BROWSER
RMI2-001
RMI2-002
RMI2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RMI2-001
ENSP00000310356
ENST00000312499
Q96E14 [Direct mapping]
RecQ-mediated genome instability protein 2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
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 147 aa
15.9 kDa 		No 0
RMI2-002
ENSP00000461206
ENST00000572173
Q96E14 [Direct mapping]
RecQ-mediated genome instability protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
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 84 aa
9.3 kDa 		No 0
RMI2-005
ENSP00000459601
ENST00000576027
I3L2E0 [Direct mapping]
RecQ-mediated genome instability protein 2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 27 aa
2.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.