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High cytoplasmic expression in squamous epithelia and lower expression in a few other cell types such as urothelia, prostate and respiratory epithelia.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data.
Squamous cell carcinomas and urothelial carcinomas showed strong positivity. Malignant carcinoids, gliomas and lymphomas together with testicular and renal cancers were negative. Remaining malignant tissues displayed generally moderate cytoplasmic positivity.
Urothelial cancer, squamous cell carcinomas of skin, lung and cervix as well as several cases of prostate cancers showed moderate to strong cytoplasmic immunoreactivity often combined with additional nuclear positivity. Remaining malignancies were generally negative.
Squamous cell carcinomas and a few urothelial cancers showed moderate to strong cytoplasmic and nuclear positivity. Other malignant tissues were negative.
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001836 [release of cytochrome c from mitochondria] GO:0003334 [keratinocyte development] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006469 [negative regulation of protein kinase activity] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008426 [protein kinase C inhibitor activity] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010467 [gene expression] GO:0010482 [regulation of epidermal cell division] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0012501 [programmed cell death] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030216 [keratinocyte differentiation] GO:0030307 [positive regulation of cell growth] GO:0030659 [cytoplasmic vesicle membrane] GO:0031424 [keratinization] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043588 [skin development] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0046827 [positive regulation of protein export from nucleus] GO:0051219 [phosphoprotein binding] GO:0051726 [regulation of cell cycle] GO:0061024 [membrane organization] GO:0061436 [establishment of skin barrier] GO:0070062 [extracellular exosome] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]