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High cytoplasmic expression in squamous epithelia and lower expression in a few other cell types such as urothelia, prostate and respiratory epithelia.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data.
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001836 [release of cytochrome c from mitochondria] GO:0003334 [keratinocyte development] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006469 [negative regulation of protein kinase activity] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008426 [protein kinase C inhibitor activity] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010467 [gene expression] GO:0010482 [regulation of epidermal cell division] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0012501 [programmed cell death] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030216 [keratinocyte differentiation] GO:0030307 [positive regulation of cell growth] GO:0030659 [cytoplasmic vesicle membrane] GO:0031424 [keratinization] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043588 [skin development] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0046827 [positive regulation of protein export from nucleus] GO:0051219 [phosphoprotein binding] GO:0051726 [regulation of cell cycle] GO:0061024 [membrane organization] GO:0061436 [establishment of skin barrier] GO:0070062 [extracellular exosome] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]