Tissue expression of HOXD8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HOXD8
Gene description	Homeobox D8
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (epididymis, kidney)
GTEx:	Tissue enhanced (kidney)
FANTOM5:	Mixed

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (epididymis, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	HOXD8 (HGNC Symbol)
Synonyms	HOX4, HOX4E
Description	Homeobox D8 (HGNC Symbol)
Entrez gene summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	176129694 - 176132695
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000175879 (version 83.38)
Entrez gene	3234
UniProt	P13378 (UniProt - Evidence at transcript level)
neXtProt	NX_P13378
Antibodypedia	HOXD8 antibodies

PROTEIN BROWSER

HOXD8-001	HOXD8-002	HOXD8-003	HOXD8-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXD8-001 ENSP00000315949 ENST00000313173	P13378 [Direct mapping] Homeobox protein Hox-D8 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008595 [anterior/posterior axis specification, embryo] GO:0009952 [anterior/posterior pattern specification] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048705 [skeletal system morphogenesis] Show all	290 aa 31.9 kDa	No	0
HOXD8-002 ENSP00000406045 ENST00000429017	A0A0A0MSX5 [Direct mapping] Homeobox protein Hox-D8 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] Show all	106 aa 12.9 kDa	No	0
HOXD8-003 ENSP00000409026 ENST00000450510	P13378 [Direct mapping] Homeobox protein Hox-D8 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008595 [anterior/posterior axis specification, embryo] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	289 aa 31.8 kDa	No	0
HOXD8-004 ENSP00000437431 ENST00000544999	A0A0A0MTF4 [Direct mapping] Homeobox protein Hox-D8 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] Show all	186 aa 21.6 kDa	No	0