Cell atlas - IP6K1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

IP6K1

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli fibrillar center
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	IP6K1
Gene description	Inositol hexakisphosphate kinase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (supported)
Additional location	In addition localized to the Nucleus (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA040825
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus & cytosol.

Main location

Nucleoli fibrillar center (supported)

Additional location

Nucleus (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040825	A-431	Nucleus
	HPA040825	A-431	Nucleoli fibrillar center
	HPA040825	U-2 OS	Nucleoli fibrillar center
	HPA040825	U-2 OS	Cytosol
	HPA040825	U-251 MG	Nucleoli fibrillar center

GENE INFORMATION
Gene name	IP6K1 (HGNC Symbol)
Synonyms	IHPK1, KIAA0263
Description	Inositol hexakisphosphate kinase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49724294 - 49786542
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176095 (version 83.38)
Entrez gene	9807
UniProt	Q92551 (UniProt - Evidence at protein level)
neXtProt	NX_Q92551
Antibodypedia	IP6K1 antibodies

PROTEIN BROWSER

IP6K1-001	IP6K1-002	IP6K1-003	IP6K1-201	IP6K1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IP6K1-001 ENSP00000323780 ENST00000321599	Q92551 [Direct mapping] Inositol hexakisphosphate kinase 1 A0A024R2X2 [Target identity:100%; Query identity:100%] Inositol hexaphosphate kinase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000832 [inositol hexakisphosphate 5-kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0052723 [inositol hexakisphosphate 1-kinase activity] GO:0052724 [inositol hexakisphosphate 3-kinase activity] Show all	441 aa 50.2 kDa	No	0
IP6K1-002 ENSP00000420467 ENST00000468463	C9JNA8 [Direct mapping] Inositol hexakisphosphate kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity] GO:0016310 [phosphorylation] Show all	274 aa 31.3 kDa	No	0
IP6K1-003 ENSP00000420762 ENST00000460540	Q92551 [Direct mapping] Inositol hexakisphosphate kinase 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000832 [inositol hexakisphosphate 5-kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0052723 [inositol hexakisphosphate 1-kinase activity] GO:0052724 [inositol hexakisphosphate 3-kinase activity] Show all	276 aa 31.5 kDa	No	0
IP6K1-201 ENSP00000378659 ENST00000395238	Q92551 [Direct mapping] Inositol hexakisphosphate kinase 1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000832 [inositol hexakisphosphate 5-kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0052723 [inositol hexakisphosphate 1-kinase activity] GO:0052724 [inositol hexakisphosphate 3-kinase activity] Show all	276 aa 31.5 kDa	No	0
IP6K1-202 ENSP00000482032 ENST00000613416	Q92551 [Direct mapping] Inositol hexakisphosphate kinase 1 A0A024R2X2 [Target identity:100%; Query identity:100%] Inositol hexaphosphate kinase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000832 [inositol hexakisphosphate 5-kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0052723 [inositol hexakisphosphate 1-kinase activity] GO:0052724 [inositol hexakisphosphate 3-kinase activity] Show all	441 aa 50.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.