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IP6K1

GENERAL INFORMATION

Gene name

 IP6K1

Gene description

 Inositol hexakisphosphate kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA040825
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040825

GENE INFORMATION

Gene name

 IP6K1 (HGNC Symbol)

Synonyms

 IHPK1, KIAA0263

Description

 Inositol hexakisphosphate kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 49724294 - 49786542

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176095 (version 83.38)

Entrez gene

 9807

UniProt

 Q92551 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92551

Antibodypedia

 IP6K1 antibodies

PROTEIN BROWSER
IP6K1-001
IP6K1-002
IP6K1-003
IP6K1-201
IP6K1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IP6K1-001
ENSP00000323780
ENST00000321599
Q92551 [Direct mapping]
Inositol hexakisphosphate kinase 1
A0A024R2X2 [Target identity:100%; Query identity:100%]
Inositol hexaphosphate kinase 1, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 441 aa
50.2 kDa 		No 0
IP6K1-002
ENSP00000420467
ENST00000468463
C9JNA8 [Direct mapping]
Inositol hexakisphosphate kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
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 274 aa
31.3 kDa 		No 0
IP6K1-003
ENSP00000420762
ENST00000460540
Q92551 [Direct mapping]
Inositol hexakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 276 aa
31.5 kDa 		No 0
IP6K1-201
ENSP00000378659
ENST00000395238
Q92551 [Direct mapping]
Inositol hexakisphosphate kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 276 aa
31.5 kDa 		No 0
IP6K1-202
ENSP00000482032
ENST00000613416
Q92551 [Direct mapping]
Inositol hexakisphosphate kinase 1
A0A024R2X2 [Target identity:100%; Query identity:100%]
Inositol hexaphosphate kinase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
Show all
 441 aa
50.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.