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Nuclear and nucleolar expression in several tissues most abundant in cells in seminiferous ducts.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Few testicular, urothelial and pancreatic cancers showed moderate nuclear/nucleolar positivity. Other cancer were in general weakly stained or negative.
Most cancer tissues exhibited weak to moderate granular cytoplasmic and occasional nuclear positivity. A few liver cancer showed strong positivity. Cervical, head and neck, most breast, skin, testicular and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SGF29 (HGNC Symbol)
Synonyms
CCDC101, FLJ32446, TDRD29
Description
SAGA complex associated factor 29 (HGNC Symbol)
Entrez gene summary
CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]