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PLA2G16

GENERAL INFORMATION

Gene name

 PLA2G16

Gene description

 Phospholipase A2, group XVI

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, CAPAN-2)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene. Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA058997
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and thyroid cancer (favourable).
Pancreatic cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA058997

GENE INFORMATION

Gene name

 PLA2G16 (HGNC Symbol)

Synonyms

 AdPLA, H-REV107-1, HRASLS3, HREV107, HREV107-3, MGC118754.

Description

 Phospholipase A2, group XVI (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

Chromosome location (bp)

 63573195 - 63616883

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176485 (version 83.38)

Entrez gene

 11145

UniProt

 P53816 (UniProt - Evidence at protein level)

neXtProt

 NX_P53816

Antibodypedia

 PLA2G16 antibodies

PROTEIN BROWSER
PLA2G16-001
PLA2G16-003
PLA2G16-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G16-001
ENSP00000320337
ENST00000323646
P53816 [Direct mapping]
HRAS-like suppressor 3
A0A024R561 [Target identity:100%; Query identity:100%]
HRAS-like suppressor 3, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004623 [phospholipase A2 activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0008654 [phospholipid biosynthetic process]
GO:0008970 [phosphatidylcholine 1-acylhydrolase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016042 [lipid catabolic process]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0052739 [phosphatidylserine 1-acylhydrolase activity]
GO:0052740 [1-acyl-2-lysophosphatidylserine acylhydrolase activity]
Show all
 162 aa
17.9 kDa 		No 1
PLA2G16-003
ENSP00000442576
ENST00000540943
F5H7E5 [Direct mapping]
HRAS-like suppressor 3
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 27 aa
3 kDa 		No 0
PLA2G16-201
ENSP00000389124
ENST00000415826
P53816 [Direct mapping]
HRAS-like suppressor 3
A0A024R561 [Target identity:100%; Query identity:100%]
HRAS-like suppressor 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004623 [phospholipase A2 activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0008970 [phosphatidylcholine 1-acylhydrolase activity]
GO:0016021 [integral component of membrane]
GO:0016042 [lipid catabolic process]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0052739 [phosphatidylserine 1-acylhydrolase activity]
GO:0052740 [1-acyl-2-lysophosphatidylserine acylhydrolase activity]
Show all
 162 aa
17.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.