Cell atlas - B3GNT5 - The Human Protein Atlas

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B3GNT5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	B3GNT5
Gene description	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017292
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017292	A-431	No staining
	HPA017292	U-2 OS	No staining
	HPA017292	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	B3GNT5 (HGNC Symbol)
Synonyms	B3GN-T5, beta3Gn-T5
Description	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183253244 - 183298504
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176597 (version 83.38)
Entrez gene	84002
UniProt	Q9BYG0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYG0
Antibodypedia	B3GNT5 antibodies

PROTEIN BROWSER

B3GNT5-001	B3GNT5-002	B3GNT5-003	B3GNT5-006	B3GNT5-007	B3GNT5-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B3GNT5-001 ENSP00000316173 ENST00000326505	Q9BYG0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005622 [intracellular] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0008378 [galactosyltransferase activity] GO:0008457 [beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity] GO:0009247 [glycolipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047256 [lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity] Show all	378 aa 44.1 kDa	No	0
B3GNT5-002 ENSP00000420778 ENST00000460419	Q9BYG0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005622 [intracellular] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0007417 [central nervous system development] GO:0008378 [galactosyltransferase activity] GO:0008457 [beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity] GO:0009247 [glycolipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047256 [lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity] Show all	378 aa 44.1 kDa	No	0
B3GNT5-003 ENSP00000417868 ENST00000465010	Q9BYG0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005622 [intracellular] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0007417 [central nervous system development] GO:0008378 [galactosyltransferase activity] GO:0008457 [beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity] GO:0009247 [glycolipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047256 [lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity] Show all	378 aa 44.1 kDa	No	0
B3GNT5-006 ENSP00000418785 ENST00000464191	C9IYY0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	62 aa 7.5 kDa	No	0
B3GNT5-007 ENSP00000418477 ENST00000464923	C9J5K2 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	81 aa 9.8 kDa	No	0
B3GNT5-011 ENSP00000417301 ENST00000481531	C9J368 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	50 aa 6.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.