Expression of B3GNT5 in cancer - Summary - The Human Protein Atlas

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B3GNT5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	B3GNT5
Gene description	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA017292
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017292

GENE INFORMATION
Gene name	B3GNT5 (HGNC Symbol)
Synonyms	B3GN-T5, beta3Gn-T5
Description	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183253244 - 183298504
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176597 (version 83.38)
Entrez gene	84002
UniProt	Q9BYG0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYG0
Antibodypedia	B3GNT5 antibodies

PROTEIN BROWSER

B3GNT5-001	B3GNT5-002	B3GNT5-003	B3GNT5-006	B3GNT5-007	B3GNT5-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B3GNT5-001 ENSP00000316173 ENST00000326505	Q9BYG0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005622 [intracellular] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0008378 [galactosyltransferase activity] GO:0008457 [beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity] GO:0009247 [glycolipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047256 [lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity] Show all	378 aa 44.1 kDa	No	0
B3GNT5-002 ENSP00000420778 ENST00000460419	Q9BYG0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005622 [intracellular] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0007417 [central nervous system development] GO:0008378 [galactosyltransferase activity] GO:0008457 [beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity] GO:0009247 [glycolipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047256 [lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity] Show all	378 aa 44.1 kDa	No	0
B3GNT5-003 ENSP00000417868 ENST00000465010	Q9BYG0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005622 [intracellular] GO:0006486 [protein glycosylation] GO:0006493 [protein O-linked glycosylation] GO:0007417 [central nervous system development] GO:0008378 [galactosyltransferase activity] GO:0008457 [beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity] GO:0009247 [glycolipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047256 [lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity] Show all	378 aa 44.1 kDa	No	0
B3GNT5-006 ENSP00000418785 ENST00000464191	C9IYY0 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	62 aa 7.5 kDa	No	0
B3GNT5-007 ENSP00000418477 ENST00000464923	C9J5K2 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	81 aa 9.8 kDa	No	0
B3GNT5-011 ENSP00000417301 ENST00000481531	C9J368 [Direct mapping] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	50 aa 6.1 kDa	No	0

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