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BOK

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GENERAL INFORMATION

Gene name

 BOK

Gene description

 BCL2-related ovarian killer

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 BOK (HGNC Symbol)

Synonyms

 BCL2L9, BOKL, MGC4631

Description

 BCL2-related ovarian killer (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241558721 - 241574138

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176720 (version 83.38)

Entrez gene

 666

UniProt

 Q9UMX3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UMX3

Antibodypedia

 BOK antibodies

PROTEIN BROWSER
BOK-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BOK-001
ENSP00000314132
ENST00000318407
Q9UMX3 [Direct mapping]
Bcl-2-related ovarian killer protein
A0A024R4A8 [Target identity:100%; Query identity:100%]
BCL2-related ovarian killer, isoform CRA_a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007420 [brain development]
GO:0008283 [cell proliferation]
GO:0008584 [male gonad development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016021 [integral component of membrane]
GO:0031966 [mitochondrial membrane]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048709 [oligodendrocyte differentiation]
GO:0051400 [BH domain binding]
GO:0051402 [neuron apoptotic process]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 212 aa
23.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.