Tissue expression of BOK - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BOK
Gene description	BCL2-related ovarian killer
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	BOK (HGNC Symbol)
Synonyms	BCL2L9, BOKL, MGC4631
Description	BCL2-related ovarian killer (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	241558721 - 241574138
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176720 (version 83.38)
Entrez gene	666
UniProt	Q9UMX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UMX3
Antibodypedia	BOK antibodies

PROTEIN BROWSER

BOK-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BOK-001 ENSP00000314132 ENST00000318407	Q9UMX3 [Direct mapping] Bcl-2-related ovarian killer protein A0A024R4A8 [Target identity:100%; Query identity:100%] BCL2-related ovarian killer, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007420 [brain development] GO:0008283 [cell proliferation] GO:0008584 [male gonad development] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048709 [oligodendrocyte differentiation] GO:0051400 [BH domain binding] GO:0051402 [neuron apoptotic process] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1900119 [positive regulation of execution phase of apoptosis] Show all	212 aa 23.3 kDa	No	1