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BASP1

GENERAL INFORMATION

Gene name

 BASP1

Gene description

 Brain abundant, membrane attached signal protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HeLa, SiHa)
HPA (normal tissue):Tissue enhanced (cerebral cortex, epididymis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA045218
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045218

GENE INFORMATION

Gene name

 BASP1 (HGNC Symbol)

Synonyms

 CAP-23, CAP23, NAP-22, NAP22

Description

 Brain abundant, membrane attached signal protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]

Chromosome

 5

Cytoband

 p15.1

Chromosome location (bp)

 17065598 - 17276843

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176788 (version 83.38)

Entrez gene

 10409

UniProt

 P80723 (UniProt - Evidence at protein level)

neXtProt

 NX_P80723

Antibodypedia

 BASP1 antibodies

PROTEIN BROWSER
BASP1-001
BASP1-003
BASP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BASP1-001
ENSP00000319281
ENST00000322611
P80723 [Direct mapping]
Brain acid soluble protein 1
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007356 [thorax and anterior abdomen determination]
GO:0008180 [COP9 signalosome]
GO:0008406 [gonad development]
GO:0016607 [nuclear speck]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0031982 [vesicle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060421 [positive regulation of heart growth]
GO:0060539 [diaphragm development]
GO:0070062 [extracellular exosome]
GO:0072075 [metanephric mesenchyme development]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:2001076 [positive regulation of metanephric ureteric bud development]
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 227 aa
22.7 kDa 		No 0
BASP1-003
ENSP00000476090
ENST00000606445
U3KQP0 [Direct mapping]
Brain acid soluble protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 46 aa
4.9 kDa 		No 0
BASP1-201
ENSP00000482066
ENST00000616743
P80723 [Direct mapping]
Brain acid soluble protein 1
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007356 [thorax and anterior abdomen determination]
GO:0008180 [COP9 signalosome]
GO:0008406 [gonad development]
GO:0016607 [nuclear speck]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0031982 [vesicle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060421 [positive regulation of heart growth]
GO:0060539 [diaphragm development]
GO:0070062 [extracellular exosome]
GO:0072075 [metanephric mesenchyme development]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:2001076 [positive regulation of metanephric ureteric bud development]
Show all
 227 aa
22.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.