Cell atlas - PNMA1 - The Human Protein Atlas

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PNMA1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Focal adhesion sites

Human cell
	Actin Filaments
	Cytosol

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GENERAL INFORMATION
Gene name	PNMA1
Gene description	Paraneoplastic Ma antigen 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the focal adhesion sites.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Focal adhesion sites (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA003817 , HPA015007
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the focal adhesion sites.

Main location

Cytosol (supported)

Additional location

Focal adhesion sites (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA015007	A-431	No staining
HPA015007	U-2 OS	Cytosol
HPA015007	U-251 MG	Cytosol
HPA003817	A-431	Cytosol
HPA003817	U-2 OS	No staining
HPA003817	U-251 MG	Focal adhesion sites
HPA003817	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PNMA1 (HGNC Symbol)
Synonyms	MA1
Description	Paraneoplastic Ma antigen 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	73711783 - 73714372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176903 (version 83.38)
Entrez gene	9240
UniProt	Q8ND90 (UniProt - Evidence at protein level)
neXtProt	NX_Q8ND90
Antibodypedia	PNMA1 antibodies

PROTEIN BROWSER

PNMA1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNMA1-001 ENSP00000318914 ENST00000316836	Q8ND90 [Direct mapping] Paraneoplastic antigen Ma1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002437 [inflammatory response to antigenic stimulus] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0043065 [positive regulation of apoptotic process] Show all	353 aa 39.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.