Expression of PNMA1 in cancer - Summary - The Human Protein Atlas

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PNMA1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PNMA1
Gene description	Paraneoplastic Ma antigen 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several cell types, most abundant in neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA003817 , HPA015007
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), urothelial cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001 Urothelial cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003817	HPA015007

GENE INFORMATION
Gene name	PNMA1 (HGNC Symbol)
Synonyms	MA1
Description	Paraneoplastic Ma antigen 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	73711783 - 73714372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176903 (version 83.38)
Entrez gene	9240
UniProt	Q8ND90 (UniProt - Evidence at protein level)
neXtProt	NX_Q8ND90
Antibodypedia	PNMA1 antibodies

PROTEIN BROWSER

PNMA1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNMA1-001 ENSP00000318914 ENST00000316836	Q8ND90 [Direct mapping] Paraneoplastic antigen Ma1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002437 [inflammatory response to antigenic stimulus] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0043065 [positive regulation of apoptotic process] Show all	353 aa 39.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.