Cell atlas - MUC20 - The Human Protein Atlas

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MUC20

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	MUC20
Gene description	Mucin 20, cell surface associated
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the plasma membrane.
RNA cell category	Cell line enriched (SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042249
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the plasma membrane.

Main location

Nucleoplasm (approved), Cytosol (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042249	A-431	Nucleoplasm
	HPA042249	A-431	Cytosol
	HPA042249	RT4	Nucleoplasm
	HPA042249	RT4	Cytosol
	HPA042249	U-2 OS	Nucleoplasm
	HPA042249	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	MUC20 (HGNC Symbol)
Synonyms	FLJ14408, KIAA1359
Description	Mucin 20, cell surface associated (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	195720882 - 195741123
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176945 (version 83.38)
Entrez gene	200958
UniProt	Q8N307 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N307
Antibodypedia	MUC20 antibodies

PROTEIN BROWSER

MUC20-001	MUC20-002	MUC20-004	MUC20-011	MUC20-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MUC20-001 ENSP00000414350 ENST00000447234	Q8N307 [Direct mapping] Mucin-20 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005796 [Golgi lumen] GO:0006493 [protein O-linked glycosylation] GO:0009925 [basal plasma membrane] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031528 [microvillus membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0051260 [protein homooligomerization] Show all	709 aa 72 kDa	Yes	0
MUC20-002 ENSP00000396774 ENST00000436408	C9JJE7 [Direct mapping] Mucin-20 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		723 aa 73.1 kDa	Yes	0
MUC20-004 ENSP00000405629 ENST00000445522	Q8N307 [Direct mapping] Mucin-20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005796 [Golgi lumen] GO:0006493 [protein O-linked glycosylation] GO:0009925 [basal plasma membrane] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0031528 [microvillus membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051260 [protein homooligomerization] Show all	674 aa 68.3 kDa	No	0
MUC20-011 ENSP00000397774 ENST00000423938	H7C102 [Direct mapping] Mucin-20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13.3 kDa	No	0
MUC20-201 ENSP00000325431 ENST00000320736	E9PH32 [Direct mapping] Mucin-20 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		538 aa 55.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.