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DPP7

GENERAL INFORMATION

Gene name

 DPP7

Gene description

 Dipeptidyl-peptidase 7

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues. Additional plasma staining in

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA021282 , CAB025541
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and pancreatic cancer (favourable).
Colorectal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA021282
CAB025541

GENE INFORMATION

Gene name

 DPP7 (HGNC Symbol)

Synonyms

 DPPII

Description

 Dipeptidyl-peptidase 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137110542 - 137115177

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176978 (version 83.38)

Entrez gene

 29952

UniProt

 Q9UHL4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHL4

Antibodypedia

 DPP7 antibodies

PROTEIN BROWSER
DPP7-003
DPP7-007
DPP7-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPP7-003
ENSP00000360635
ENST00000371579
Q9UHL4 [Direct mapping]
Dipeptidyl peptidase 2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0008236 [serine-type peptidase activity]
GO:0008239 [dipeptidyl-peptidase activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031982 [vesicle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0070062 [extracellular exosome]
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 492 aa
54.3 kDa 		Yes 0
DPP7-007
ENSP00000473618
ENST00000497375
R4GNE8 [Direct mapping]
Dipeptidyl peptidase 2
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   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006508 [proteolysis]
GO:0008236 [serine-type peptidase activity]
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 272 aa
29.4 kDa 		Yes 0
DPP7-008
ENSP00000473309
ENST00000463619
R4GMR2 [Direct mapping]
Dipeptidyl peptidase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006508 [proteolysis]
GO:0008236 [serine-type peptidase activity]
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 244 aa
26.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.