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CETN1

GENERAL INFORMATION

Gene name

 CETN1

Gene description

 Centrin, EF-hand protein, 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in testis and ciliated cells of fallopian tube.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA028956 , CAB037244
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028956
CAB037244

GENE INFORMATION

Gene name

 CETN1 (HGNC Symbol)

Synonyms

 CEN1, CETN

Description

 Centrin, EF-hand protein, 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]

Chromosome

 18

Cytoband

 p11.32

Chromosome location (bp)

 580357 - 582114

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177143 (version 83.38)

Entrez gene

 1068

UniProt

 Q12798 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12798

Antibodypedia

 CETN1 antibodies

PROTEIN BROWSER
CETN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CETN1-001
ENSP00000319052
ENST00000327228
Q12798 [Direct mapping]
Centrin-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000922 [spindle pole]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0007067 [mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0032391 [photoreceptor connecting cilium]
GO:0032795 [heterotrimeric G-protein binding]
GO:0034605 [cellular response to heat]
GO:0051301 [cell division]
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 172 aa
19.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.