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HIC1

GENERAL INFORMATION

Gene name

 HIC1

Gene description

 Hypermethylated in cancer 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ, TIME)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA043372
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA043372

GENE INFORMATION

Gene name

 HIC1 (HGNC Symbol)

Synonyms

 ZBTB29, ZNF901

Description

 Hypermethylated in cancer 1 (HGNC Symbol)

Entrez gene summary

 This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 2054154 - 2063241

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177374 (version 83.38)

Entrez gene

 3090

UniProt

 Q14526 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14526

Antibodypedia

 HIC1 antibodies

PROTEIN BROWSER
HIC1-001
HIC1-002
HIC1-003
HIC1-004
HIC1-005
HIC1-006
HIC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIC1-001
ENSP00000461476
ENST00000574370
Q70SM2 [Direct mapping]
Hypermethylated in cancer 1; Hypermethylated in cancer 1 protein
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Predicted intracellular proteins
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 9 aa
1 kDa 		No 0
HIC1-002
ENSP00000476554
ENST00000571875
V9GYA4 [Direct mapping]
Hypermethylated in cancer 1 protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 66 aa
7.4 kDa 		No 0
HIC1-003
ENSP00000460268
ENST00000571990
I3L388 [Direct mapping]
Hypermethylated in cancer 1 protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 96 aa
10.5 kDa 		No 0
HIC1-004
ENSP00000467045
ENST00000576444
K7ENQ1 [Direct mapping]
Hypermethylated in cancer 1 protein
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 84 aa
9.5 kDa 		No 0
HIC1-005
ENSP00000314080
ENST00000322941
Q14526 [Direct mapping]
Hypermethylated in cancer 1 protein
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0042826 [histone deacetylase binding]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
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 733 aa
76.5 kDa 		No 0
HIC1-006
ENSP00000477858
ENST00000619757
Q14526 [Direct mapping]
Hypermethylated in cancer 1 protein
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0042826 [histone deacetylase binding]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
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 714 aa
74.5 kDa 		No 0
HIC1-201
ENSP00000382742
ENST00000399849
Q14526 [Direct mapping]
Hypermethylated in cancer 1 protein
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0042826 [histone deacetylase binding]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 714 aa
74.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.