Tissue expression of HIC1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HIC1
Gene description	Hypermethylated in cancer 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA043372
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	HIC1 (HGNC Symbol)
Synonyms	ZBTB29, ZNF901
Description	Hypermethylated in cancer 1 (HGNC Symbol)
Entrez gene summary	This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	2054154 - 2063241
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177374 (version 83.38)
Entrez gene	3090
UniProt	Q14526 (UniProt - Evidence at protein level)
neXtProt	NX_Q14526
Antibodypedia	HIC1 antibodies

PROTEIN BROWSER

HIC1-001	HIC1-002	HIC1-003	HIC1-004	HIC1-005	HIC1-006	HIC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIC1-001 ENSP00000461476 ENST00000574370	Q70SM2 [Direct mapping] Hypermethylated in cancer 1; Hypermethylated in cancer 1 protein Show all	Predicted intracellular proteins Show all		9 aa 1 kDa	No	0
HIC1-002 ENSP00000476554 ENST00000571875	V9GYA4 [Direct mapping] Hypermethylated in cancer 1 protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	66 aa 7.4 kDa	No	0
HIC1-003 ENSP00000460268 ENST00000571990	I3L388 [Direct mapping] Hypermethylated in cancer 1 protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	96 aa 10.5 kDa	No	0
HIC1-004 ENSP00000467045 ENST00000576444	K7ENQ1 [Direct mapping] Hypermethylated in cancer 1 protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	84 aa 9.5 kDa	No	0
HIC1-005 ENSP00000314080 ENST00000322941	Q14526 [Direct mapping] Hypermethylated in cancer 1 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016055 [Wnt signaling pathway] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0042826 [histone deacetylase binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	733 aa 76.5 kDa	No	0
HIC1-006 ENSP00000477858 ENST00000619757	Q14526 [Direct mapping] Hypermethylated in cancer 1 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016055 [Wnt signaling pathway] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0042826 [histone deacetylase binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	714 aa 74.5 kDa	No	0
HIC1-201 ENSP00000382742 ENST00000399849	Q14526 [Direct mapping] Hypermethylated in cancer 1 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016055 [Wnt signaling pathway] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0042826 [histone deacetylase binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	714 aa 74.5 kDa	No	0