Cell atlas - PPFIA3 - The Human Protein Atlas

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PPFIA3

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Vesicles

Human cell
	Nucleoli
	Vesicles

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GENERAL INFORMATION
Gene name	PPFIA3
Gene description	Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center) & vesicles.
RNA cell category	Cell line enhanced (PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (uncertain), Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA043567
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center) & vesicles.

Main location

Nucleoli fibrillar center (uncertain), Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043567	PC-3	No staining
	HPA043567	U-2 OS	No staining
	HPA043567	U-251 MG	Nucleoli fibrillar center
	HPA043567	U-251 MG	Vesicles

GENE INFORMATION
Gene name	PPFIA3 (HGNC Symbol)
Synonyms	KIAA0654, LPNA3, MGC126567, MGC126569
Description	Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49119389 - 49151026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177380 (version 83.38)
Entrez gene	8541
UniProt	O75145 (UniProt - Evidence at protein level)
neXtProt	NX_O75145
Antibodypedia	PPFIA3 antibodies

PROTEIN BROWSER

PPFIA3-001	PPFIA3-003	PPFIA3-006	PPFIA3-007	PPFIA3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPFIA3-001 ENSP00000335614 ENST00000334186	O75145 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0009986 [cell surface] GO:0014047 [glutamate secretion] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0048786 [presynaptic active zone] Show all	1194 aa 133.5 kDa	No	0
PPFIA3-003 ENSP00000473621 ENST00000602509	R4GNF1 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007269 [neurotransmitter secretion] GO:0048786 [presynaptic active zone] Show all	147 aa 16.7 kDa	No	0
PPFIA3-006 ENSP00000473622 ENST00000602351	O75145 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0009986 [cell surface] GO:0014047 [glutamate secretion] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0048786 [presynaptic active zone] Show all	1185 aa 132.4 kDa	No	0
PPFIA3-007 ENSP00000473418 ENST00000602848	A0A0C4DGR7 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0048786 [presynaptic active zone] Show all	277 aa 31.3 kDa	No	0
PPFIA3-008 ENSP00000473423 ENST00000602897	A0A0C4DGR8 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0048786 [presynaptic active zone] Show all	243 aa 27.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.