Expression of PPFIA3 in cancer - Summary

GENERAL INFORMATION
Gene name	PPFIA3
Gene description	Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (PC-3)
HPA (normal tissue):	Group enriched (cerebral cortex, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in brain, peripheral ganglion cells and most squamous epithelial tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA043567 , HPA050340
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), liver cancer (unfavourable), breast cancer (unfavourable) and endometrial cancer (favourable).
Head and neck cancer p<0.001 Liver cancer p<0.001 Breast cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043567	HPA050340

GENE INFORMATION
Gene name	PPFIA3 (HGNC Symbol)
Synonyms	KIAA0654, LPNA3, MGC126567, MGC126569
Description	Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49119389 - 49151026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177380 (version 83.38)
Entrez gene	8541
UniProt	O75145 (UniProt - Evidence at protein level)
neXtProt	NX_O75145
Antibodypedia	PPFIA3 antibodies

PROTEIN BROWSER

PPFIA3-001	PPFIA3-003	PPFIA3-006	PPFIA3-007	PPFIA3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPFIA3-001 ENSP00000335614 ENST00000334186	O75145 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0009986 [cell surface] GO:0014047 [glutamate secretion] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0048786 [presynaptic active zone] Show all	1194 aa 133.5 kDa	No	0
PPFIA3-003 ENSP00000473621 ENST00000602509	R4GNF1 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007269 [neurotransmitter secretion] GO:0048786 [presynaptic active zone] Show all	147 aa 16.7 kDa	No	0
PPFIA3-006 ENSP00000473622 ENST00000602351	O75145 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0009986 [cell surface] GO:0014047 [glutamate secretion] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0048786 [presynaptic active zone] Show all	1185 aa 132.4 kDa	No	0
PPFIA3-007 ENSP00000473418 ENST00000602848	A0A0C4DGR7 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0048786 [presynaptic active zone] Show all	277 aa 31.3 kDa	No	0
PPFIA3-008 ENSP00000473423 ENST00000602897	A0A0C4DGR8 [Direct mapping] Liprin-alpha-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0048786 [presynaptic active zone] Show all	243 aa 27.6 kDa	No	0