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NR2C2

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GENERAL INFORMATION

Gene name

 NR2C2

Gene description

 Nuclear receptor subfamily 2, group C, member 2

Protein class

 Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA006313
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006313 A-431 Nucleoplasm
HPA006313 U-2 OS Nucleoplasm
HPA006313 U-251 MG Nucleoplasm

siRNA VALIDATION

Antibody

 HPA006313

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA and > 10% by the other.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 83%67%

p-value

 < 0.01< 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA006313 siRNA 1 U-2 OS
HPA006313 siRNA 2 U-2 OS
HPA006313 scrambled U-2 OS

GENE INFORMATION

Gene name

 NR2C2 (HGNC Symbol)

Synonyms

 hTAK1, TAK1, TR2R1, TR4

Description

 Nuclear receptor subfamily 2, group C, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 14947584 - 15053600

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177463 (version 83.38)

Entrez gene

 7182

UniProt

 P49116 (UniProt - Evidence at protein level)

neXtProt

 NX_P49116

Antibodypedia

 NR2C2 antibodies

PROTEIN BROWSER
NR2C2-001
NR2C2-002
NR2C2-004
NR2C2-006
NR2C2-008
NR2C2-009
NR2C2-011
NR2C2-012
NR2C2-201
NR2C2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR2C2-001
ENSP00000320447
ENST00000323373
P49116 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
F2YGU2 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 2, group C, member 2, isoform CRA_a; Testicular nuclear receptor 4
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030154 [cell differentiation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 615 aa
67.3 kDa 		No 0
NR2C2-002
ENSP00000388387
ENST00000425241
P49116 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030154 [cell differentiation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 596 aa
65.4 kDa 		No 0
NR2C2-004
ENSP00000376814
ENST00000393102
P49116 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030154 [cell differentiation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 596 aa
65.4 kDa 		No 0
NR2C2-006
ENSP00000402272
ENST00000413118
C9JMI6 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 67 aa
6.9 kDa 		No 0
NR2C2-008
ENSP00000391473
ENST00000435454
C9J2Y1 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 36 aa
3.7 kDa 		No 0
NR2C2-009
ENSP00000401807
ENST00000437120
C9JKS0 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 205 aa
22.3 kDa 		No 0
NR2C2-011
ENSP00000412473
ENST00000439011
H7C3L1 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 222 aa
25.2 kDa 		No 0
NR2C2-012
ENSP00000413438
ENST00000413194
H7C3R1 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 173 aa
19.8 kDa 		No 0
NR2C2-201
ENSP00000384463
ENST00000406272
P49116 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030154 [cell differentiation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 596 aa
65.4 kDa 		No 0
NR2C2-202
ENSP00000483059
ENST00000617312
P49116 [Direct mapping]
Nuclear receptor subfamily 2 group C member 2
F2YGU2 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 2, group C, member 2, isoform CRA_a; Testicular nuclear receptor 4
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0021549 [cerebellum development]
GO:0030154 [cell differentiation]
GO:0038066 [p38MAPK cascade]
GO:0040019 [positive regulation of embryonic development]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048520 [positive regulation of behavior]
GO:0051321 [meiotic cell cycle]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 615 aa
67.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.