Cell atlas - NHLH2 - The Human Protein Atlas

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NHLH2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NHLH2
Gene description	Nescient helix loop helix 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.
RNA cell category	Cell line enriched (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Additional location	In addition localized to the Nucleoplasm (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055238
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.

Main location

Nuclear bodies (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055238	HEK 293	Nuclear bodies
	HPA055238	SiHa	Nucleoplasm	Spatial
	HPA055238	SiHa	Nuclear bodies	Spatial
	HPA055238	U-2 OS	Nucleoplasm	Spatial
	HPA055238	U-2 OS	Nuclear bodies	Spatial

GENE INFORMATION
Gene name	NHLH2 (HGNC Symbol)
Synonyms	bHLHa34, HEN2, NSCL2
Description	Nescient helix loop helix 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p13.1
Chromosome location (bp)	115836377 - 115843917
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177551 (version 83.38)
Entrez gene	4808
UniProt	Q02577 (UniProt - Evidence at protein level)
neXtProt	NX_Q02577
Antibodypedia	NHLH2 antibodies

PROTEIN BROWSER

NHLH2-001	NHLH2-002	NHLH2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NHLH2-001 ENSP00000358519 ENST00000369506	Q02577 [Direct mapping] Helix-loop-helix protein 2 A0A024R0I7 [Target identity:100%; Query identity:100%] Nescient helix loop helix 2, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0007417 [central nervous system development] GO:0030154 [cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] Show all	135 aa 15 kDa	No	0
NHLH2-002 ENSP00000322087 ENST00000320238	Q02577 [Direct mapping] Helix-loop-helix protein 2 A0A024R0I7 [Target identity:100%; Query identity:100%] Nescient helix loop helix 2, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0007417 [central nervous system development] GO:0030154 [cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] Show all	135 aa 15 kDa	No	0
NHLH2-003 ENSP00000405062 ENST00000429731	A6PVY9 [Direct mapping] Helix-loop-helix protein 2 Show all	Predicted intracellular proteins Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	107 aa 11.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.