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NHLH2

GENERAL INFORMATION

Gene name

 NHLH2

Gene description

 Nescient helix loop helix 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA055238
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055238

GENE INFORMATION

Gene name

 NHLH2 (HGNC Symbol)

Synonyms

 bHLHa34, HEN2, NSCL2

Description

 Nescient helix loop helix 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p13.1

Chromosome location (bp)

 115836377 - 115843917

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177551 (version 83.38)

Entrez gene

 4808

UniProt

 Q02577 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02577

Antibodypedia

 NHLH2 antibodies

PROTEIN BROWSER
NHLH2-001
NHLH2-002
NHLH2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NHLH2-001
ENSP00000358519
ENST00000369506
Q02577 [Direct mapping]
Helix-loop-helix protein 2
A0A024R0I7 [Target identity:100%; Query identity:100%]
Nescient helix loop helix 2, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Basic domains
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0030154 [cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
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 135 aa
15 kDa 		No 0
NHLH2-002
ENSP00000322087
ENST00000320238
Q02577 [Direct mapping]
Helix-loop-helix protein 2
A0A024R0I7 [Target identity:100%; Query identity:100%]
Nescient helix loop helix 2, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0030154 [cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
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 135 aa
15 kDa 		No 0
NHLH2-003
ENSP00000405062
ENST00000429731
A6PVY9 [Direct mapping]
Helix-loop-helix protein 2
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Predicted intracellular proteins
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
Show all
 107 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.